Abstract Review With Dr. Robert Wong

Clinical Vignettes

July 2025

In this expert commentary, Dr. Robert Wong, a hepatologist at Stanford University School of Medicine and the VA Palo Alto Health Care System, highlights an important abstract presented by Dr. Gao and colleagues on the clinical value of quantitative hepatitis B surface antigen (qHBsAg) testing. This study underscores how qHBsAg levels can help guide treatment decisions and predict the likelihood of achieving a functional cure in patients with chronic hepatitis B. Most notably, the findings reveal that the accuracy and sensitivity of the assay used are critical—highly sensitive tests are significantly better at predicting sustained HBsAg clearance and identifying the risk of seroreversion. Dr. Wong emphasizes the need to incorporate qHBsAg testing more routinely in clinical practice and to ensure the use of high-quality assays for optimal patient outcomes. Tune in to learn how advancements in diagnostic testing are shaping the future of hepatitis B care.