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Challenges in Diagnosing CHB

Podcast

In this educational video, Helen Adams, PA-C, and Emily Przybyl, PA-C, provide a comprehensive discussion on chronic hepatitis B—from diagnosis and screening to monitoring and reactivation risk. With over 250 million people worldwide affected and roughly 1 million deaths annually, the need for early detection and evidence-based management is critical. The PAs walk through proper HBV serology interpretation, highlight the importance of triple panel testing (surface antigen, surface antibody, and core antibody), and address commonly missed steps in screening and staging. They also explain the role of non-invasive fibrosis testing, underscore the need for hepatocellular carcinoma (HCC) surveillance, and review reactivation risks in immunocompromised patients. Practical takeaways include tips for interpreting “tricky” labs, avoiding overlooked HBV history in HIV patients, and navigating updated guideline sources such as AASLD and the AGA. Whether you're a new provider or experienced clinician, this conversation offers essential insights into improving outcomes for patients with chronic hepatitis B.